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Following oral administrationpeak hydrochlorothiazide plasma levels are attained in approximately 2 hoursIt is excreted rapidly and unchanged in the urine.

MAXZIDE should not be used in patients who are hypersensitive to triamterene or hydrochlorothiazide or other sulfonamide-derived drugs.

Calcium excretion is decreased by thiazidesPathological changes in the parathyroid gland with hypercalcemia and hypophosphatemia have been observed in a few patients on prolonged thiazide therapyThe common complications of hyperparathyroidism such as renal lithiasisbone resorptionand peptic ulceration have not been seenThiazides should be discontinued before carrying out tests for parathyroid function.

Cardiovasculartachycardiashortness of breath and chest painorthostatic hypotensionmay be aggravated by alcoholbarbiturates or narcotics

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the frequent combination of hydrochlorothiazide and triamterene is always an effective medication for hypertension.