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Rare cases of increase in transaminases and in alkaline phosphatase and hepatitis that may be serious have been reportedThere have been reports of hepatic failure observed with the use of XENICAL in postmarketing surveillancewith some of these cases resulting in liver transplant or deathsee WARNINGS AND PRECAUTIONSRare cases of hypersensitivity have been reported with the use of XENICALSigns and symptoms have included pruritusrashurticariaangioedemabronchospasm and anaphylaxisVery rare cases of bullous eruption have been reportedRare cases of leukocytoclastic vasculitis have been reportedClinical signs include palpablepurpuramaculopapular lesionsor bullous eruptionAcute oxalate nephropathy after treatment with XENICAL has been reported in patients with or at risk for renal diseasesee WARNINGS AND PRECAUTIONSPancreatitis has been reported with the use of XENICAL in postmarketing surveillanceNo causal relationship or physiopathological mechanism between pancreatitis and obesity therapy has been definitively establishedLower gastrointestinal bleeding has been reported in patients treated with XENICALMost reports are nonserioussevere or persistent cases should be investigated further.

Patients should be counseled to take XENICAL as directed with meals or up to one hour after a mealPatients should also be advised to take multivitamin supplementation at least two hours before or after the administration of XENICALor at bedtimesee DOSAGE AND ADMINISTRATION

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orligal orlistat is a gastrointestinal lipase inhibitor for obesitymanagement that acts by inhibiting the absorption of dietary fats.