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REVIEWER’S CONCLUSIONSFor people with schizophrenia olanzapine may offer antipsychotic efficacy with fewer extrapyramidal side effects than typical drugs but more weight gainThe large proportions of participants leaving the studies earlyin the large multi-centre trials makes it difficult to draw firm conclusions on clinical effectsLargelong-term randomised trials with participantsinterventions and primary outcomes that are familiar to those wishing to help those with schizophrenia are long overdue.

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plasma concentrations of olanzapine or carbamazepine did not reveal a meaningful relationship.