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Potentiated by CYP3A4 inhibitorsegketoconazolemacrolidescyclosporineestrogensAntagonized by CYP3A4 inducersegbarbituratesphenytoincarbamazepinerifampincholestyramineMay potentiate cyclosporineseizure riskMay antagonize oral anticoagulantsmonitorisoniazidIncreased risk of arrhythmias with digitalisMay need to adjust dose of antidiabetic agentsMonitor for hypokalemia with potassium-depleting drugsegamphotericin BdiureticsConcomitant neuromuscular blocking agentsincreased risk of myopathyWithdraw anticholinesterase agents at least 24hrs before initiating corticosteroid therapyAminoglutethimide may lead to loss of corticosteroid-induced adrenal suppressionIncreased GI effects with aspirinother NSAIDsCaution with aspirin in hypoprothrombinemiaMay suppress reactions to skin tests.

Potentiated by CYP3A4 inhibitorsegketoconazolemacrolidescyclosporineestrogensAntagonized by CYP3A4 inducersegbarbituratesphenytoincarbamazepinerifampincholestyramineMay potentiate cyclosporineseizure riskMay antagonize oral anticoagulantsmonitorisoniazidIncreased risk of arrhythmias with digitalisMay need to adjust dose of antidiabetic agentsMonitor for hypokalemia with potassium-depleting drugsegamphotericin BdiureticsConcomitant neuromuscular blocking agentsincreased risk of myopathyWithdraw anticholinesterase agents at least 24hrs before initiating corticosteroid therapyAminoglutethimide may lead to loss of corticosteroid-induced adrenal suppressionIncreased GI effects with aspirinother NSAIDsCaution with aspirin in hypoprothrombinemiaMay suppress reactions to skin tests.

The action of DEPO-MEDROL Sterile Aqueous Suspension injected intrasynovially appears to be well localized since significant metabolic effects characteristic of systemic administration of adrenal steroids have not been observedIn a few instances mild and transient improvement of structures other than those injected have been reportedNo other systemic effects have been notedHoweverit is possible that mild systemic effects may occur following intrasynovial administrationand this possibility is greater the larger the number of structures injected and the higher the total dose employed.

Therapeutic Good’s AdministrationTGAPharmaceutical Benefits SchemePBSGuildLink DrugBank.

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