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Before using this medicationtell your doctor or pharmacist your medical historyespecially ofasthmableeding/clotting problemsblood disorderse.ganemiahigh blood pressurediabetesheart diseasee.ghistory of heart attackliver diseasegrowths in the nosenasal polypsobesitytobacco usehistory of stomach/intestine/esophagus problemse.gbleedingulcersrecurring heartburnstrokeswelling of the ankles/feet/hands.

Take with or without foodTake with food if it causes an upset stomachTake with a full glass of water.

Mefenamic acid pharmacokinetics have not been investigated in subjects with renal insufficiencyGiven that mefenamic acidits metabolites and conjugates are primarily excreted by the kidneysthe potential exists for mefenamic acid metabolites to accumulatePonstel should not be administered to patients with pre-existing renal disease or in patients with significantly impaired renal functionsee WARNINGSRenal Toxicity and Hyperkalemia

Based on its physical and chemical propertiesPonstel is expected to be excreted in human breast milksee PRECAUTIONSNursing Mothers

Known hypersensitivitye.ganaphylactic reactions and serious skin reactionsto mefenamic acid or any components of the drug productsee WARNINGSAnaphylactic ReactionsSerious Skin ReactionsHistory of asthmaurticariaor other allergic-type reactions after taking aspirin or other NSAIDsSeveresometimes fatalanaphylactic reactions to NSAIDs have been reported in such patientssee WARNINGSAnaphylactic ReactionExacerbation of Asthma Related to Aspirin SensitivityIn the setting of coronary artery bypass graftCABGsurgerysee WARNINGSCardiovascular Thrombotic Events

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