Do not take this medicine with any of the following medications -arsenic trioxide -certain antibiotics like grepafloxacin, pentamidine, sparfloxacin -certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole -certain medicines for malaria like chloroquine, halofantrine -certain medicines for irregular heart beat like dofetilide, dronedarone -cisapride -droperidol -levomethadyl -methadone -pimozide -ranolazine -risperidone -thioridazine -ziprasidone this medicine may also interact with the following medications -alcohol -atropine -benztropine -cabergoline -carbamazepine -certain medicines for depression, anxiety, or psychotic disturbances -certain medicines for parkinson s disease like levodopa -certain medicines that treat or prevent blood clots like warfarin -dicyclomine -lithium -narcotic medicines for pain -other medicines that prolong the qt interval cause an abnormal heart rhythm -promethazine -rifampin.

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Since promethazine HCI administered intravenouslyby injectioncan cause severe chemical irritation and damage to tissuesdeep intramuscular injectiona technique administering medication deep into the musclesis the preferred method of injectionPromethazine hydrochloride injections should not be given by intra-arterialwithin an arteryinjectionunder any circumstancesdue to the risk of severe arteriospasmspasm in an arteryand resulting gangrene.

Sedating drugs may cause confusion and over-sedation in the elderlyelderly patients generally should be started on low doses of promethazine hydrochloride tablets and observed closely.

Dry mouth drowsiness listlessness difficulty falling asleep or staying asleep nightmares dizziness ringing in ears blurred or double vision loss of coordination nausea vomiting nervousness restlessness hyperactivity abnormally happy mood stuffy nose itching.

Promethazine is used to treat allergy symptoms such as itchingrunny nosesneezingitchy or watery eyeshivesand itchy skin rashesIt also prevents motion sicknessand treats nausea and vomiting or pain after surgeryIt is also used as a sedative or sleep aid.

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phenylephrine; promethazine moderate sympathomimetics may increase blood glucose concentrations.