8 ml contains 20 mg methotrexate.

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Methotrexate is usually given after other medications have been tried without successful treatment of symptoms.

In rare instancesthis drug may also cause liver problems when it is used for long periods of timeIf you are using methotrexate long terma liver biopsy is usually recommended.

Nonsteroidal anti-inflammatory drugsNSAIDssuch as ibuprofennaproxenaspirindiclofenacetodolacor ketoprofenIncreased side effects can include bleedingproblems with your bone marrowor serious problems with your digestive tractThese problems can be fatalcause deathSeizure drugs such as phenytoinIncreased side effects can include upset stomachhair losstirednessweaknessand dizzinessGout drugs such as probenecidIncreased side effects can include upset stomachhair losstirednessweaknessand dizzinessAntibiotics such as penicillin drugswhich include amoxicillinampicillincloxacillinand nafcillinIncreased side effects can include upset stomachhair losstirednessweaknessand dizzinessProton pump inhibitors such as omeprazolepantoprazoleor esomeprazoleIncreased side effects can include upset stomachhair losstirednessweaknessand dizzinessSkin drugs such as retinoidsIncreased side effects can include liver problemsPost-transplant drugs such as azathioprineIncreased side effects can include liver problemsAnti-inflammatory drugs such as sulfasalazineIncreased side effects can include liver problemsAntibiotics such as trimethoprim/sulfamethoxazoleIncreased side effects can include bone marrow damageNitrous oxidean anesthesia drugIncreased side effects can include mouth soresnerve damageand a reduction in blood cell counts that may increase your risk of infection.

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ketoprofen major in general, nsaid therapy can decrease the clearance of methotrexate, resulting in elevated and prolonged serum methotrexate levels.